Very likely!

This was published shortly before the Chicago World’s Fair opened in 1893.
Brother Jonathan [the icon did not fully stabilize under “Uncle Sam” until World War I]: “Don’t be angry with me, dear immigrants, for having you fumigated so severely as you enter America. Right now cholera is the excuse, but then it will improve during the exhibition in Chicago!”
(Nebelspalter, Zurich, 1892)